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Summary
This study investigates the effects of Assisted Reproductive Technology (ART) on genome-wide DNA methylation and gene expression in human placentas. The results show that ART is associated with changes in DNA methylation and gene expression, particularly in pathways related to hormonal regulation, insulin secretion, and vascularization.
Highlights
- ART is associated with changes in DNA methylation and gene expression in human placentas.
- The changes are particularly significant in pathways related to hormonal regulation, insulin secretion, and vascularization.
- The study found decreased expression of TRIM28, NOTCH3, and DLK1 in ART placentas.
- The changes in DNA methylation and gene expression are linked to increased risks of metabolic and heart disorders.
- The study suggests that the effects of ART on the placenta may contribute to the increased risks of adverse outcomes in ART-conceived children.
- The study highlights the importance of considering the potential epigenetic effects of ART on the placenta and the developing fetus.
- The study's findings have implications for our understanding of the long-term effects of ART on human health.
Key Insights
- The study's findings suggest that ART may have a profound impact on the epigenetic regulation of gene expression in the placenta, which may contribute to the increased risks of adverse outcomes in ART-conceived children.
- The decreased expression of TRIM28, NOTCH3, and DLK1 in ART placentas is particularly concerning, as these genes play critical roles in regulating cell growth, differentiation, and survival.
- The study's results highlight the importance of considering the potential epigenetic effects of ART on the placenta and the developing fetus, and suggest that further research is needed to fully understand the long-term consequences of ART on human health.
- The changes in DNA methylation and gene expression observed in this study may be related to the increased risks of metabolic and heart disorders in ART-conceived children, and suggest that ART may have a lasting impact on the epigenetic regulation of gene expression in the placenta.
- The study's findings have implications for our understanding of the long-term effects of ART on human health, and suggest that further research is needed to fully understand the potential risks and benefits of ART.
- The study's results suggest that the effects of ART on the placenta may be sex-specific, with males and females exhibiting different patterns of DNA methylation and gene expression.
- The study's findings highlight the importance of considering the potential epigenetic effects of ART on the placenta and the developing fetus, and suggest that further research is needed to fully understand the long-term consequences of ART on human health.
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Citation
Auvinen, P., Vehviläinen, J., Rämö, K., Laukkanen, I., Marjonen-Lindblad, H., Wallén, E., Söderström-Anttila, V., Kahila, H., Hydén-Granskog, C., Tuuri, T., Tiitinen, A., & Kaminen-Ahola, N. (2024). Genome-wide DNA methylation and gene expression in human placentas derived from assisted reproductive technology. In Communications Medicine (Vol. 4, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1038/s43856-024-00694-6